In vitro activity of imipenem/relebactam plus aztreonam against metallo-β-lactamase-producing, OprD-deficient Pseudomonas aeruginosa with varying levels of Pseudomonas-derived cephalosporinase production

J Nicholas O'Donnell,Vibert Putra,Gina M Belfiore,Brittney L Maring,Katherine Young,Thomas P Lodise

International Journal of Antimicrobial Agents（2022）

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摘要

•3 parent and 7 MBL-producing daughter strains were evaluated•The addition of I/R restored ATM susceptibility in 5 of 7 MBL-producing isolates•Time-kill studies showed synergy for isolates with constitutive PDC production•Time-kill results for ATM plus REL were similar to those with I/R plus ATM

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Pseudomonas aeruginosa,Metallo-β-lactamases,Imipenem/relebactam,Aztreonam,Synergy

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