Dual ligand engagement for noncanonical inflammasome activation
NATURE IMMUNOLOGY(2022)
摘要
The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.
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关键词
Infection,Inflammasome,Innate immunity,Biomedicine,general,Immunology,Infectious Diseases
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