Dynamic changes in clinical characteristics and serotype distribution of invasive pneumococcal disease among adults in Japan after introduction of the pediatric 13-valent pneumococcal conjugate vaccine in 2013–2019

•Adult patients with IPD in Japan were analyzed by time periods in 2013 –2019.•Serotype PCV13-nonPCV7 decreased in adult IPD patients after pediatric PCV13 use.•Serotype PPSV23-nonPCV13 remained unchanged in those aged 15–64 y and ≥ 65 y.•Nonvaccine serotypes increased in those aged ≥ 65 y, but not in those aged 15–64 y.•2018–2019 was independently associated with a lower risk of fatal outcome.