Effect of S-Nitrosylation of RIP3 Induced by Cerebral Ischemia on its Downstream Signaling Pathway

Yi Zhong, Peng Peng, Mengmeng Zhang,Dong Han,Hongning Yang,Xianliang Yan,Shuqun Hu

Journal of Stroke and Cerebrovascular Diseases（2022）

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摘要

•Activated RIP3 further phosphorylate RIP1 and mixed lineage kinase-like domains (MLKL).•Activated RIP3 further promote the conversion of Caspase8 to active Cleaved-Caspase8 (Cl-Caspase8).•Activated RIP3 further enhance the activities of Glycogen phosphorylase (PYGL), Glutamate-ammonia ligase (GLUL) and Glutamate dehydrogenase (GLUD1).

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关键词

RIP3,S-nitrosylation,Cerebral ischemia,Downstream signaling

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