Genetic reprogramming of remnant duodenum may contribute to type 2 diabetes improvement after Roux-en-Y gastric bypass

Priscila Sala,Natasha Mendonça Machado,Raquel Susana Matos de Miranda Torrinhas,Danielle C Fonseca, Beatriz Am Ferreira,Robson Kiyoshi Ishida,Ismael Francisco Mota Siqueira Guarda,Eduardo Guimarães Hourneaux de Moura,Paulo Sakai,Marco Aurélio Santo,Steven B Heymsfield,Maria Lúcia Corrêa-Giannella,Dan Linetzky Waitzberg

Nutrition（2022）

引用 2|浏览11

暂无评分

摘要

•In obese women with type 2 diabetes subjected to Roux-en-Y gastric bypass, intestinal adaptations to its new anatomy included changes in gene expression.•Some differentially expressed genes correlated with markers of glucose homeostasis in this population.•Transcriptomic findings in duodenum appeared to affect lipogenesis and cholesterol efflux in these women.•Duodenal transcriptomic changes correlated with remission of postoperative diabetes in this group.

查看译文

关键词

Gene expression,Obesity,Gastric bypass,Glycemia,Duodenum, LXR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要