Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes

Tony Rady,Michel Mosser,Marc Nothisen,Stephane Erb,Igor Dovgan,Sarah Cianférani,Alain Wagner,Guilhem Chaubet

RSC ADVANCES（2021）

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摘要

Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue - BCN acid - whose facile functionalization via amide bond formation yields more stable derivatives than the classically encountered carbamates.

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