MiR-21 regulates epithelial–mesenchymal transition in intestinal fibrosis of Crohn's disease by targeting PTEN/mTOR

Zhizhi Wang,Huihui Zhou,Fei Cheng,Zhendong Zhang,Shunhua Long

Digestive and Liver Disease（2022）

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摘要

We identified the involvement of miR-21 in EMT during intestinal fibrosis via targeting PTEN and mTOR, and miR-21 inhibition relieved intestinal fibrosis by regulating extracellular matrix (ECM) remodeling . Our results indicated miR-21 as a potential new target for the treatment of fibrosis complication in CD.

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关键词

Crohn's disease,Epithelial–mesenchymal transition,Intestinal fibrosis,miRNA-21,PTEN

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