IBF-R, a botanical extract of Rhus verniciflua controls obesity in which AMPK-SIRT1 axis and ROS regulatory mechanism are involved in mice

The-Hiep Hoang,Young Yoon,Seon-Ah Park,Hwa-Young Lee,Cheng Peng,Jung-Hyun Kim,Geum-Hwa Lee,Han-Jung Chae

Journal of Functional Foods（2021）

引用 8|浏览2

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摘要

•IBF-R inhibited mTOR-SREBP1-ER stress-mitochondrial axis.•IBF-R reduced fat accumulation via AMPK/SIRT1 activation, controlling ER stress.•IBF-R prevented obesity by regulating adipogenesis, lipogenesis and thermogenesis.

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关键词

Rhus verniciflua,Obesity,AMPK,SIRT1,PGC1α deacetylation

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