Polypeptide coatings on biominerals with superior antimicrobial and antifouling properties inspired by human salivary proteins

Xiao Yang,Feng Lou,Weihao Yuan, Wanyin Song,Yiyuan Xue,Duan Wang,Yuchen Guo,Xu Peng,Xinyuan Xu,Chuang Liu,Ruibo Zhao,Xiao Yang,Xianlong Wang,Chunmei Ding,Liming Bian,Jianshu Li

Applied Materials Today（2022）

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摘要

•Design and synthesis of a bioinspired multifunctional polypeptide P1-SAP.•Characterization of the self-assembly and adsorption of P1-SAP on biomineral HA surface.•Characterization of P1-SAP coated bio-interface in terms of in vitro antibacterial and antibiofouling functions.•Demonstration of in vivo wound healing and anti-infection properties of P1-SAP coated bio-interface.

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关键词

Saliva acquired pellicle,Statherian,Histatin,Anti-biofilm,Superhydrophilicity

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