Use of sildenafil in patients with severe COVID-19 pneumonitis

parenchymal a persistent perfusion defect on follow-up We report outcomes with sildenafil in a well characterized cohort of ARDS patients with pulmonary hypertension or RV dysfunction due to COVID-19. While a single sildenafil dose can cause hypotension and deterioration in oxygenation in ARDS (without associated pulmonary hypertension or RV dysfunction), this study suggests sildenafil was well tolerated in COVID-19 ARDS, without a deterioration in oxygenation, dead space or haemodynamics, and improved cardiac biomarkers and echocardiographic features. longer