Immunoinformatic screening of Marburgvirus epitopes and computational investigations of epitope-allele complexes

Prabin Baral,Elumalai Pavadai,Ziyou Zhou,Yang Xu, Christopher K. Tison,Rudramani Pokhrel,Bernard S. Gerstman,Prem P. Chapagain

International Immunopharmacology（2022）

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摘要

•Used immunoinformatic tools to screen the T-cell and B-cell epitopes for the Marburgvirus proteins GP, NP, VP24, VP30, VP35, VP40, and L.•Performed consensus and novelty analysis to identify potential vaccine candidate epitopes.•Investigated the atomistic details of the epitope-allele complexes for the GP and NP epitopes using molecular dynamics simulations.

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关键词

Epitopes,Marburg virus,In silico prediction,Vaccine design,Molecular dynamics,Bioinformatics

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