A Pilot Study of In Vivo Longitudinal Monitoring of Structure and Angiogenesis for Melanoma/Pancreatic Tumor using Optical Coherence Tomography

Pancreatic tumors and melanoma are two types of cancers with high mortality. Monitoring the tumor microenvironment during growth plays an important role in studying the property of tumors. To study the progression of pancreatic tumors and melanoma in vivo, we propose to use optical coherence tomography (OCT) to monitor the tumor structure and angiogenesis in mouse in a longitudinal manner. Our results demonstrate that OCT is a promising tool to longitudinally monitor the change and progression of structure, tissue distribution, and microvasculature in pancreatic and melanoma tumor models. OCT can serve as a promising modality to provide structural and microvascular information for future anti-cancer treatment and drug development.