Trends in Glycemic among Youth with Diabetes: The SEARCH for Diabetes in Youth Study
semanticscholar(2022)
摘要
OBJECTIVES: To describe temporal
trends and correlates of glycemic control in youth and young adults (YYA) with
youth-onset diabetes.
RESEARCH DESIGN AND METHODS: The
study included 6,492 participants with type 1 or type 2 diabetes from the SEARCH
for Diabetes in Youth study. Participant visit data were categorized into time
periods 2002-2007, 2008-2013 and 2014-2019, diabetes durations of 1-4, 5-9, and
10+ years, and age groups 1-9, 10-14, 15-19, 20-24, 25+ years. Participants
contributed one randomly selected data point to each duration and age group per
time period. Multivariable regression models were used to test differences in
hemoglobin A1c (HbA1c) over time by diabetes type. Models
were adjusted for site, age, sex, race/ethnicity, household income, health
insurance status, insulin regimen and diabetes duration, overall and stratified
for each duration and age group.
RESULTS: Adjusted mean HbA1c for the 2014-2019 cohort of YYA with
type 1 diabetes was 8.8%±0.04%. YYA with type 1 diabetes in the 10-14, 15-19, and 20-24 age
groups from the 2014-2019 cohort had worse glycemic control than the 2002-2007 cohort.
Race/ethnicity, household income and treatment regimen predicted differences in
glycemic control in 2014-2019 type 1 diabetes participants. Adjusted mean HbA1c was 8.6%±0.12%
for 2014-2019 YYA with type 2 diabetes. Participants
age 25+ with type 2 diabetes had worse glycemic control relative to the
2008-2013 cohort. Only treatment regimen was associated with differences in
glycemic control in type 2 diabetes participants.
CONCLUSIONS: Despite advances in diabetes technologies, medications, and
dissemination of more aggressive glycemic targets, many current YYA are less
likely to achieve desired glycemic control relative to earlier cohorts.
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