STING Mediates Pulmonary Hypertension Through VEGF but Independent of Type I Interferon Signaling

Ann Pham,Yuanqing Lu,Laylo Mukhsinova,Chunhua Fu,Oliveira Aline,Lei Jin,Andrew Bryant

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE（2022）

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摘要

Global absence of STING provided protection against PH development secondary to chronic hypoxia and Bleomycin in mice. However, this protective effect is independent of type I interferon signaling. Interestingly, STING-mediated VEGF expression may play a protective role against PH development.

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