Antagonism of Na,K‐ATPase Signaling by Pnaktide Can Attenuate Systemic Inflammatory Response in Murine Sepsis Model Induced by Cecal Ligation and Puncture

Oxidative stress and associated inflammatory processes are crucial in the development and progression of sepsis, resulting in an immune response that leads to multiple organ failure or dysfunction. Hence, the strategies to limit this systemic inflammatory response might result in the development of an effective sepsis therapy. Previous studies from our lab have demonstrated the role of Na/K‐ATPase signaling in exacerbating systemic oxidative stress and inflammation and the potential role of Na/K‐ATPase signaling antagonist, pNaKtide, in ameliorating several pathophysiological abnormalities.