Climate Factors May Influence Glomerular Filtration Rate in Nephrology Patients.

Ambient humidity demonstrated a robust and resilient effect on kidney function. Higher humidity corresponded to a reduction in estimated GFR across all stages of CKD and within stages. Other climate factors exhibited no effect. A possible mechanism is the decrease in evaporative cooling leading to additional sweat loss, reduced plasma volume, and a lower blood pressure gradient in the glomerulus.