LIGHT Deficiency Protects Against Esophageal Remodeling In A Murine Model Of Chronic Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is an eosinophil predominant, chronic allergic disease with increasing prevalence. Tissue remodeling is a hallmark complication in EoE and associates with clinical dysphagia and strictures. We recently defined a putative role for TNFSF14/LIGHT in promoting an inflammatory esophageal fibroblast phenotype. However, the effects of LIGHT deficiency on EoE pathogenesis in vivo remain unknown. Here we investigated the impact of LIGHT deficiency in a murine model of chronic EoE.