Post Vaccination Effects of m-RNA Covid-19 Vaccine & Its Efficacy with Detailed Self-Reported Symptoms from Healthcare Workers and General Population in Central Gujarat

Background & Aim: Concerns are prevailing about the safety and side effects of the mRNA vaccine for coronavirus disease 2019 (COVID-19). Hence a study aiming the effectiveness of vaccine, post vaccination symptoms, natural progression of infection in the individuals was performed. Methods: A randomized, cross-sectional survey was performed comprising the 757 individuals from the pool of 1000 people, to investigate the side effects of the vaccines using an independent online questionnaire gathering responses from healthcare workers (HCWs) and general population with detailed review of organ systems. Results: A total of 757 people responded, led us to the point where 476 people (62.87 %) of people experiencing minimum one symptom following the first dose of either of the two vaccine, in comparison to 188 responses (24.8%) of people experiencing at least one symptom following second dose of either of the two vaccine. Conclusion: Commonly reported symptoms (occurrence in descending order) were soreness, fatigue, myalgia, headache, chills, fever, joint pain, nausea, muscle spasm, sweating, dizziness, flushing, feelings of relief, brain fogging, anorexia, localized swelling, decreased sleep quality, itching, tingling, diarrhea, nasal stuffiness and palpitations. Despite this, remarkable acceptance for the second dose of the m-RNA Covid vaccine was found among all the individuals.