Local Photothermal/photodynamic Synergistic Antibacterial Therapy Based on Two-Dimensional BP@CQDs Triggered by Single NIR Light Source

Pathogenic bacteria-infected wound healing faces challenges even though many advanced antibiotics and antibacterial nanoagents have been developed. Herein, we established a two-dimensional antibacterial nanoplatform with synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) antibacterial capabilities mediated by a single 808 nm laser irradiation. The nanoplatform is constructed by combining black phosphorus (BP) obtained by liquid phase exfoliation and hydrothermally prepared tellurium-doped carbon quantum dots (CQDs) prepared by electrostatic interaction. As a result, the photothermal conversion of BP and hydroxyl radical (center dot OH) production of CQDs under NIR laser makes the nanoplatform (BP@CQDs) possess an outstanding antibacterial performance against S. aureus and E. coli (as high as 92.7% and 98.4%, respectively), resulting in a faster wound closure ratio than another infected wound. Moreover, in vitro and in vivo researches showed that BP@CQDs have good hemocompatibility, cytocompatibility, and biocompatibility during the therapeutic process. This work demonstrates the broad application prospect of BP nanosheets in infectious microenvironments and develops a potential strategy for S. aureus-infected wound repair.