Convenient preparation of synthetically useful chiral quaternary carbon-containing bicyclic compounds with organocatalysts

Yuichiro Kawamoto,Naoki Noguchi,Daiki Ozone,Toyoharu Kobayashi,Hisanaka Ito

TETRAHEDRON LETTERS（2021）

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摘要

Chiral quaternary carbon-containing bicyclic compounds possessing carbonyl functionalities were effi-ciently synthesized through asymmetric intramolecular aldol reactions with organocatalysts. Bicyclo [3.3.0] and [3.4.0] systems were constructed with a diamine catalyst, while bicyclo [4.3.0] and [4.4.0] skeletons were prepared by an acylsulfonamide type catalyst. (c) 2021 Elsevier Ltd. All rights reserved.

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关键词

Asymmetric desymmetrization, Diamine type organocatalyst, Acylsulfonamide type organocatalyst, Intramolecular aldol reaction, Chiral quaternary carbon

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