Synthesis and antiproliferative activity of novel organometallic cobalt(III) complex encapsulated in polydiacetylene-phospholipid nanoformulation

Arangasamy Mounica,Chandrasekar Balachandran,Durairaj Gopalakrishnan,Pandiyan Sivasakthi,Muthuramalingam Prakash,Shin Aoki,Mani Ganeshpandian

Inorganica Chimica Acta（2022）

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摘要

Novel organometallic Cp*Cobalt(III) complex shows remarkable cytotoxicity in lung and cervical cancer cells due to its redox behaviour and hydrophobicity and the Co(III) complex-liposome nanoaggregate exhibits less toxicity in healthy fetal lung cells.

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关键词

Cobalt-pentamethylcyclopentadienyl complexes,Schiff base ligand,Polydiacetylene-phospholipid assembly,Nano-encapsulation,Cytotoxicity

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