The effect of benzenesulfonamide's side chains on their human carbonic anhydrase Ⅰ/Ⅱ inhibitory activities

Chaofu Yang,Xianyu Sun, Zhan Li,Yunyun Cheng, Yu Lei,Liang Lu,Xuan Liu,Xiaomei Zhuang,Tao Wang,Xinhua He

Journal of Molecular Structure（2022）

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摘要

•Benzenesulfonamides with hydrophilic/ hydrophobic tails are carbonic anhydrase inhibitors (CAIs)•Benzenesulfonamides with quinary heterocycle and hydrophilic tail inhibit CA•Water-soluble benzenesulfonamides against hCAIs prolong survival in hypoxic mice•They exhibit better inhibition than that of acetazolamide against hCA I and hCA II•They offer innovative opportunities for potent, water-soluble hCA inhibitors

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关键词

Side chains,Benzenesulfonamide derivative,Dual hCA I/II inhibitor,Anti- hypoxic activity

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