Synthesis and Self‐Assembly of Amphiphilic Ferrocene‐Selenopeptide Conjugates

Ferrocene (Fc) conjugated selenopeptides were synthesized using a new modified solid‐phase peptide synthesis (SPSS) protocol and their self‐assembled nanostructure formation into spheres, nanofibers, and nanotubes studied. Four selenopeptide conjugates have been successfully prepared: two containing both selenocysteine (Sec) and Fc, the other two have either one of these units. These compounds were well‐characterized with various spectroscopic techniques, including 1D and 2D NMR. The importance of the Fc unit, aromatic moieties, and weak intermolecular interactions on the self‐assembled process was revealed by systematic morphological studies.