Efficacy of H1 receptor antagonist plus pregabalin capsules in skin pruritus: A controlled study

Purpose: To determine the effectiveness of histamine H1 receptor antagonist combined with pregabalin capsules in the treatment of skin pruritus. Methods: From June 2018 to June 2019, 90 patients who presented pruritus in the Second Hospital of Shandong University were recruited and randomized into control and study groups. The control group was treated topically with conventional drug (umiconazole ointment), while the study group was treated with the combination of histamine and H1 receptor antagonist and pregabalin capsules. Clinical efficacy for the two groups was assessed. Results: The study group obtained clinical efficiency than the control group (p 0.05); No significant difference was found in the degree of pruritus between the two groups before treatment and 12 h after treatment (p 0.05). At 48 and 72 h after treatment, the two groups showed significant differences in the degree of pruritus (p < 0.05). The study group had a significantly lower Pittsburgh Sleep Quality Index (PSQI) score after treatment when compared to the control group (p < 0.001). A lower incidence of adverse reactions was observed in the study group in contrast to the control group (p < 0.05). The level of parathyroid hormone (PTH) of the study group was significantly lower than that of the control group (p < 0.001). Conclusion: The combined use of Histamine H1 receptor antagonist with pregabalin capsule effectively alleviates the degree of pruritus, ensures good sleep quality, and lowers the incidence of adverse reactions.