Stochastic dynamic quantitative and 3D structural matrix assisted laser desorption/ionization mass spectrometric analyses of mixture of nucleosides

•Quantitative matrix-assisted laser desorption/ionization mass spectrometry.•Solid-state 3D structural analysis of analytes in mixture via MALDI-MS method.•Strustural analysis of tautomers of guanine and guanosine in solid-state mixtures.•Stochastic dynamics mass spectrometry for structural analysis in condensed phases.•Complementary quantum chemistry and mass spectrometry for 3D analysis of tautomers.