Regulation of physiological pH and consumption of potential food ingredients for maintaining homeostasis and metabolic function: An overview

Maintaining homeostasis is of utmost importance regarding human health. Several factors could protect human body's internal environment from harms and fluctuations from external environment. Regulation of physiological pH has a considerable role in maintaining human health and its metabolic functions. Several studies have shown that the interstitial body fluid pH around metabolic tissues is easily reduced due to weaker pH buffering capacity than that in the cytosol and blood circulation. Therefore, pH reduction in the interstitial fluid may cause the onset of metabolic dysfunctions. However, several dietary food components have potential benefits in maintaining the interstitial fluid pH to the normal range by improving buffering capacities, suppressing proton production, and activating proton transporters, which strengthen the effect of appropriate diet on metabolic health. Keeping deep insights about this aspect, we have summed up several facts and figures for maintaining human body homeostasis via regulation of physiological pH. Furthermore, we have discussed about different food categories and their potential renal acid load and its relation with maintaining homeostasis. Afterwards we have deeply discussed the potential beneficial role of healthy food components in different pathological conditions of human body.