Palladium‐Catalyzed Domino Cyclization/Phosphorylation of gem‐Dibromoolefins with P(O)H Compounds: Synthesis of Phosphorylated Heteroaromatics

We presented a palladium‐catalyzed domino cyclization/phosphorylation of gem‐dibromoolefins, which utilize H‐phosphinates and secondary phosphine oxides as the phosphine sources, respectively. A variety of phosphorylated heteroaromatics were obtained in moderate to good yields with wide functional group compatibility. This one‐pot reaction enables multiple bond‐forming events including C−X (X=O, N, S) and C−P bonds using easily available starting materials. Moreover, this protocol can be easily applied to large‐scale preparation and late‐stage functionalization.