Nanomaterials as novel agents for amelioration of Parkinson’s disease

•Nano-based systems are promising strategies for the amelioration of PD.•A-syn accumulation and loss of dopaminergic neurons are vital hallmarks of PD.•Nano agents aiming at diverse pathogenic mechanisms are potential solutions to the alleviation of PD.•The unity of safety and efficiency should be addressed when design nano agents in PD therapy.