Novel silicone rubber with carboxyl grafted polyhedral oligomeric silsesquioxane (POSS-COOH) as a potential scaffold for soft tissue filling

Due to the poor cell compatibility, capsular contracture is usually accompanied by the implantation of Silicone Rubber (SR). In this study, synthetical carboxyl grafted polyhedral oligomeric silsesquioxane (POSS-COOH) was incorporated into SR to prepare a composite filling material, namely POSS-COOH/SR. in vivo implantation showed that the occurrence of capsular formation around POSS-COOH/SR was inhibited, in vitro experiment showed cell improved proliferation and adhesion capability on POSS-COOH/SR. Through proteomics analysis, the extracellular matrix (ECM) regulatory protein in the cells on the surface of POSS-COOH/SR changed significantly. In summary, POSS-COOH/SR could be a better biomaterial to scaffold for soft tissue filling.