Niclosamide & challenges in chemical modifications: A broad review on enhancement of solubility

Niclosamide is classified under World Health Organization's crucial medicines and it is categorized as an anthelmintic drug to target tapeworm infections. In recent findings it is successfully repurposed as a multifunctional drug effective against many diseases. The approach for synthesis of niclosamide is very crisp, simple and affordable. Besides these outstanding activities and easy method of synthesis, the poor solubility which down regulate the bioavailability of niclosamide has prevented its advance development for clinical therapy. This article reviews various methods studied by vast researchers to enhance the solubility which lead to increased efficacy and potential in targeting the diseases. The review also focuses on the application of niclosamide derivatives in different therapeutic uses which proves its broad and vast activity to treat many diseases. The experimental studies to enhance the solubility using chemistry approaches are progressing to achieve the success in developing niclosamide based therapies and broaden its applications."The experimental study to enhance the solubility by chemistry aspect is progressing continuously to achieve the success in its uses. "Therefore, in present review we have broadly discuss the challenges, synthesis, chemical modification for solubility enhancement and application of niclosamide as gold drug in clinical field".