Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH.

Two new nor-triterpenoids ganodrenol A (), B (), and a new natural product ganodrenol C (), along with three known nor-triterpenoids (-) were isolated from the fruiting bodies of The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (-) against FAAH were evaluated by an in assay, and compound showed an inhibition rate of 70.27%. In addition, the cytotoxic effect of compounds (-) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity.