Enantioselective [3 + 2] Cycloaddition of Vinylcyclopropanes with Alkenyl N‑Heteroarenes Enabled by Palladium Catalysis

Wen-Dao Chu,Ya-Ting Wang,Tian-Tian Liang,Teng Long,Jia-Yu Zuo,Zhihui Shao,Bo Chen,Cheng-Yu He,Quan-Zhong Liu

Organic Letters（2022）

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摘要

The first catalytic enantioselective [3 + 2] cycloaddition reaction between vinylcyclopropanes and alkenyl N-heteroarenes in the presence of LiBr and a Pd(0)/SEGPHOS complex was developed. LiBr plays a key role in improving the reactivity of alkenyl N-heteroarenes as a mild Lewis acid.

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关键词

Lewis acid, tones, ? -unsaturated aldehydes, ketones, imines, Meldrum ? s, acid alkylidenes, nitroalkenes, ? -nucleobase substituted acryl-

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