Tauroursodeoxycholic acid improves glucose tolerance and reduces adiposity in normal protein and malnourished mice fed a high-fat diet

Thiago dos Reis Araujo, Mariana Roberta Rodrigues Muniz,Bruna Lourençoni Alves,Lohanna Monali Barreto dos Santos, Maressa Fernandes Bonfim, Joel Alves da Silva Junior,Jean Franciesco Vettorazzi,Cláudio Cesar Zoppi,Everardo Magalhães Carneiro

Food Research International（2022）

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摘要

•Obesity associated with undernutrition leads to an impairment in glucose and lipid homeostasis.•TUDCA increases insulin action and reduces insulin secretion in protein malnourished obese mice.•TUDCA restored metabolic flexibility and reduced adiposity in protein malnourished obese mice.•TUDCA has potential to reverse metabolic disorders in the double burden of malnutrition.

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关键词

Tauroursodeoxycholic acid,Malnutrition,Obesity,Glucose homeostasis,Insulin resistance,Lipid metabolism

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