Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia.

Andres Hernandez-Clavijo,Kevin Y Gonzalez-Velandia,Uday Rangaswamy,Giorgia Guarneri,Paolo Boscolo-Rizzo,Margherita Tofanelli,Nicoletta Gardenal,Remo Sanges,Michele Dibattista,Giancarlo Tirelli,Anna Menini

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2022）

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摘要

Our results provide the first evidence that TMEM16F is expressed in human olfactory supporting cells and indicate that syncytia formation, that could be blocked by niclosamide, is one of the pathogenic mechanisms worth investigating in COVID-19 smell loss.

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关键词

Sustentacular cells, ANO6, Human olfaction, Scramblase

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