Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer

Elena Tosti,Ana S Almeida,Tam T T Tran,Mariel Barbachan E Silva,Pilib Ó Broin,Robert Dubin,Ken Chen,Amanda P Beck,Andrew S Mclellan,Eduardo Vilar,Aaron Golden,Paul W O'Toole,Winfried Edelmann

Cellular and Molecular Gastroenterology and Hepatology（2022）

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摘要

Our results demonstrate a synergistic interaction between MMR and TGFBR2 inactivation in inflammation-associated colon tumorigenesis and highlight the crucial impact of the gut microbiota on modulating the incidence of inflammation-associated CRCs.

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关键词

DNA Mismatch Repair,Colon Cancer,Gut Microbiota,Inflammation

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