Advances in the mechanism of bile acids in liver regeneration

Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy (PHx) of the liver, which is essential for the recovery of related patients. Recent studies have found that bile acids (BA) play an important role in the process of liver regeneration. In the early stages of PHx, bile acid overload occurs, and liver injury is aggravated by loading. Later bile acids can induce protective and proliferative responses in the liver and promote liver regeneration. In this paper, we summarize the negative effects after bile acid overload and its positive role as a signaling molecule involved in related signaling pathways on liver regeneration, including protection of the liver and promotion of liver regeneration, and its double-edswordged "in Liver regeneration. This provides a theoretical basis for subsequent in-depth study of the mechanism and benefit avoidance in clinical treatment.