Failure of Translation Initiation of the Next Gene Decouples Transcription at Intercistronic Sites and the Resultant Mrna Generation
MBio(2022)
摘要
Transcription of operons is initiated at the promoter of the first gene in the operon, continues through cistron junctions, and terminates at the end of the operon, generating a full-length mRNA. Here, we show that Rho-dependent termination of transcription occurs stochastically at a cistron junction, generating a stable mRNA that is shorter than the full-length mRNA.
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关键词
transcription pausing,transcription-translation coupling,Rho-dependent transcription termination,cistron junction,gal operon
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