Human liver stem cells alleviate Con-A induced liver injury by regulating the balance of Treg/Th17 cells

Yonghong Yang,Guanjun Dong,Yanzhen Bi,Xiaobei Zhang,Xiaoying Yao,Guiyuan Jin,Kai Zhang,Zhenfeng Shu,Feng Hong

Transplant Immunology（2022）

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摘要

•We found a novel method to isolate and culture human liver stem cells (HLSCs).•HLSCs improved survival and liver injury in mice challenged with Con A.•HLSCs culture media protect mice from Con A-induced liver injury.•HLSCs transplantion reversed Treg/Th17 cell imbalance in mice challenged with Con A.

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关键词

HLSCs,Liver injury,Th17 cells,Treg cells

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