Ascaridole exerts the leishmanicidal activity by inhibiting parasite glycolysis

Deblina Sarkar,Sritama De Sarkar,Lars Gille,Mitali Chatterjee

Phytomedicine（2022）

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摘要

•Ascaridole demonstrated leishmanicidal activity towards L. donovani, the major causative agent of visceral leishmaniasis.•Ascaridole disrupted the redox homeostasis in promastigotes.•Ascaridole demonstrated glycolytic inhibition in promastigotes.•Ascaridole mediated an apoptotic-like death in promastigotes.

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关键词

Anti-leishmanial,Ascaridole,Endoperoxides,Glycolysis,Leishmaniasis,Reactive oxygen species (ROS)

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