COVID-19 Seroprevalence in ED Health Care Professionals Study: A Cross-Sectional Study

•ED health care professionals are often the first point of hospital contact for patients with an acute illness. There were concerns that ED health care professionals may have been at increased risk of exposure to SARS-CoV-2.•At a single institution, there was a seroprevalence of 2.9% for SARS-CoV-2 antibodies among ED health care professionals who had never been formally diagnosed with COVID-19.•Adherence to infection control protocols, including implementation of universal masking and use of appropriate personal protective equipment for patients with suspected or confirmed COVID-19 or confirmed exposures, can effectively mitigate risk of transmission in health care settings.