Crosstalk between IL-15Rα + tumor-associated macrophages and breast cancer cells reduces CD8 + T cell recruitment.

Wenlong Zhang,Qing Zhang,Nanfei Yang,Qian Shi,Huifang Su,Tingsheng Lin,Zhonglei He,Wenxin Wang,Hongqian Guo,Pingping Shen

Cancer communications (London, England)（2022）

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摘要

The IL-15Rc-HIF-1α-CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the tumor microenvironment of breast cancer. Targeting this pathway may provide a potential therapeutic strategy for enhancing the efficacy of cancer immunotherapy.

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关键词

CD8+ T-cell,IL-15Rα,breast cancer,crosstalk,immunotherapy,tumor microenvironment,tumor-associated macrophages

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