P231. Medial Prefrontal Cortex Activation to Reward Outcome Moderates Influence of Sexual Orientation Victimization in Adolescents and Young Adults

Sexual minority youth (SMY) are at greater risk for depression than heterosexual counterparts. Minority stress theory posits that sexual orientation victimization acts as a chronic stressor to influence depression. For those responsive to stress, stress may worsen depression by altering activity in neural reward systems. This study examines whether orientation victimization impacts neural reward activity and depression, and whether these relationships differ by SMY status.