Metabolic Changes at the Menopausal Transition

Obesity and its related severe consequences have been a major public health problem worldwide. A significant weight gain and intra-abdominal adipose tissue accumulation are observed as women begin the menopausal transition. Nowadays, the change of body weight during menopausal transition represents an important topic of discussion. A number of clinical and basic research indicate that ovarian hormone may play a crucial role. How do hormonal changes in menopause lead to alterations in lipid and glucose metabolism, fat distribution, and food intake? Understanding the ovarian hormones’ influences on lipid and glucose metabolism, and on the regulation of body weight could be an attractive target. A variety of research modalities have been used to explore the effects of MHT on body mass, body fat redistribution, and insulin resistance in perimenopausal women, which lead to protective cardiometabolic effects.