The role of U.S. thermal stress in modulating the vascular transport dynamics in the brain tumors

We hypothesized that localized thermal stress could change the cerebrovascular transport dynamics in the brain tumor micro-environment. Our findings, using a closed-loop trans-cranial MR guided FUS system, support our hypothesis and provide evidence that spatially controlled thermal stress can enable the development of therapeutic strategies to reduce systemic toxicity while attaining high drug accumulation to the tumor core.