Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production.

Long Xu,Yang Yang,Jiali Jiang,Yankai Wen,Jong-Min Jeong,Christoph Emontzpohl,Constance L Atkins,Kangho Kim,Elizabeth A Jacobsen,Hua Wang,Cynthia Ju

Hepatology (Baltimore, Md.)（2023）

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摘要

The current study revealed that eosinophil-derived IL-4/IL-13 accounted for the hepatoprotective effect of eosinophils during AILI. The data demonstrated that the p38 MAPK/COX/NF-κB signaling cascade played a critical role in inducing IL-4/IL-13 production by eosinophils in response to IL-33.

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