Copy number alterations in stage I epithelial ovarian cancer highlight three genomic patterns associated with prognosis

Chiara Pesenti,Luca Beltrame,Angelo Velle,Robert Fruscio,Marta Jaconi,Fulvio Borella, Fulvia Milena Cribiù,Enrica Calura, Lara Veronica Venturini,Deborah Lenoci,Federico Agostinis,Dionyssios Katsaros,Nicolò Panini,Tommaso Bianchi,Fabio Landoni,Monica Miozzo,Maurizio D'Incalci,James D. Brenton,Chiara Romualdi,Sergio Marchini

European Journal of Cancer（2022）

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摘要

•Stable (S), unstable (U), and highly-U (HU) profiles define the genome of stage I EOC.•S, U, and HU profiles classify each histological subtype independently of FIGO stage.•S, U, and HU profiles are shared across matched synchronous and metachronous lesions.•S, U, and HU are independent prognostic markers of overall survival.•S, U, and HU profiling is a novel approach to stratify stage I EOC clinical outcome.

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关键词

Stage I EOC,Somatic copy number alteration,Prognosis

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