Handheld Point-of-Care Device for the Quantification of Anti-SARS-CoV-2 Antibodies

Antibodies that are produced following infection due to the SARS-CoV-2 virus or vaccination are critical for monitoring the immune response of an individual or the impact of the vaccine over time. As vaccines become available, there is a need for rapid, accurate, and low-cost point-of-care tools for monitoring the effectiveness of the vaccines over time at the population level. Here, we report the efficiency of a handheld point-of-care thermo-photonic device for quantifying anti-SARS-CoV-2 antibodies in humanized control positive solution. Results showed that the imager in conjunction with rapid diagnostic tests (RDT) can detect and quantify antibody levels within clinically relevant range and with a limit of detection of 0.1 µg/ml.