Conduction study of electrophysiological signals based on in-vitro myocardial tissue

Cardiac electrophysiology and drug study on the cardiomyocyte culture make great progress. In the present study microelectrode array (MEA) was used to detect the mechanically beatings of the whole heart and the cardiac tissue slice in vitro with multi-sites. The experiment results show that the cardiac tissues in vitro can keep good status and favorable beating. Additionally, the cardiac tissue slices can maintain the structure and characteristics of the whole heart, which is accordant to the excitation-contraction coupling mechanism. Using this sensing technology based on the myocardial tissues, we synchronously obtained the electrical signals of different positions of myocardial tissue, which is helpful to judge the direction of myocardial electrical signal propagation and conduction.