Histopathological and epigenetic changes in myocardium associated with cancer therapy-related cardiac dysfunction.

Chiyoko-Ikeda Terada,Kenji Onoue,Tomomi Fujii,Hiroe Itami,Kohei Morita,Tomoko Uchiyama,Maiko Takeda,Hitoshi Nakagawa,Tomoya Nakano,Youichirou Baba,Kisaki Amemiya,Yoshihiko Saito,Kinta Hatakeyama,Chiho Ohbayashi

ESC heart failure（2022）

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摘要

Our results indicate distinct morphological characteristics in myocardial histopathology associated with CTRCD. p53 and H3K27ac histone modification could be sensitive markers of CTRCD and suggest a mechanistic involvement of epigenetic changes.

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关键词

endomyocardial biopsy,epigenetics,histone acetylation,oncocardiology,p53

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