Effects of acute high intraocular pressure on red-green and blue-yellow cortical color responses in non-human primates

•Red-green and blue-yellow responses in V1, V2, and V4 of seven rhesus macaques were compared during acute intraocular elevation.•Acute IOP elevations substantially depress the ability of the visual cortex to register color information.•Blue-yellow responses are consistently more impaired than red-green responses at all levels of acute IOP elevation, suggesting selective impairment of the koniocellular pathways compared with the parvocellular pathways.•Blue-yellow color vision might be the most vulnerable visual function in acute glaucoma patients.